TESAMORELIN
OVERVIEW
• Tesamorelin is a GHRH (Growth Hormone Releasing Hormone)
• FDA-approved drug for lipodystrophy (abnormal distribution of fat)
• The “Gold Standard” GHRH
• Enhances endogenous growth hormone creation in the body
HOW DOES IT WORK
• Tesamorelin goes up to the anterior pituitary gland and signals the
body to create growth hormone (does not mean it will be released)
• Somatostatin is the rate-limiting effect that allows the release of
growth hormone.
• By inhibiting somatostatin, it allows the body to release growth
hormone (GHRPs do this)
• It is important to combine a GHRH with a GHRP to ensure the
creation and release of growth hormone co-occurs.
RESEARCH BENEFITS
• Increase production of endogenous growth hormone
• Promotes muscle growth
• Helps with mood and stress resilience
• Slows down aging
• Improves sleep
• Promotes a balanced inflammatory response
• Improves bone density
RESEARCH SIDE EFFECTS
• Redness, itchiness, and swelling of injection sites
• Water retention
• Joint pain
• A sharp increase in IGF-1 levels
INSIGHT ON RESEARCH DOSING & CYCLING
• 500-2000 mcg per injection
• Multiple injections can be given a day to increase GH secretion. Often
used in bodybuilding
• 5 days on, 2 days off, 10-12 weeks on, 4-8 weeks off
• Carbohydrates and fatty acids can blunt growth hormone release
Best taken 30 minutes before eating or 2 hours after eating
INSIGHT ON RESEARCH TIMING & BENEFITS
• Burning Fat
# Before a workout in a fasted state
• Building Muscle
# After a workout in a fasted state
• Sleep
# Before bed in a fasted state
• General Anti-Aging
# In the morning in a fasted state
PEPTIDES $ SUPPLEMENTS YOU COULD STACK IT WITH
• Any GHRP (GHRP-2, GHRP-6, Ipamorelin, Hexarelin)
•BPC-157
• AOD-9604
• Semaglutide/Tirezeptide
• PEG-MGF
• Kisspeptin-10
• 5-Amino-1-MQ
• Natural Diuretic (reduces water retention)
• Masculine Medicine
PROS & CONS
PROS
• Strongest GHRH
• Maintains the negative feedback loop
• Strong benefits with a high safety profile
CONS
• Expensive
• Can sharply increase IGF-1 levels
