MELANOTAN I
OVERVIEW
• Melanotan I and Melanotan II work on the melanocortin system and
replicate the hormone melanocortin, which is naturally released by
the pituitary gland
• These peptides increase melanogenesis, which plays an import role in
tanning, immune support, and sexual support
• Melanotan I is often used more frequently as it has fewer side effects
than Melanotan II
• Melanotan II does display a more intense response with more benefits
but has a higher side-effect profile.
HOW DOES IT WORK
• Melanotan I mainly binds to the MC1R receptors
• Melanotan II mostly binds to MC1R, MC3R and MC4R receptors
# MCIR (melanogenesis -> tanning)
# HMC3R (suppression of appetite)
# HMCAR (enhanced sexual stimulus)
RESEARCH BENEFITS
• Helps with various skin disorders
• Supports immune system
• UV/tanning protection
• Increases libido and improves erectile function in men (Mostly
Melanotan II)
• Cardio and neuroprotective
• Supports appetite and metabolism (Mostly Melanotan II)
• Helps with alcohol abuse disorder
RESEARCH SIDE EFFECTS
• Sexual stimulation (erection lasting longer than 4 hours) Mostly
concerned with Melanotan II
• Can potentially increase blood pressure
• Nausea
• Vomiting
• Headache
• Do not use if there is a history of skin cancer
• Do not use with other PDE5 inhibitors (Viagra, Tadalafil) – Mostly
concerned with Melanotan II
INSIGHT ON RESEARCH CYCLING & DOSING
• For Tanning
# 1200 mcg daily for 1 week
# 50-100 mcg 1-2x a week after reaching the skin-tone goal
• For Immunity
# 200 mcg daily for 6-8 weeks
• For Metabolic Support
# 50 mcg daily
• For Sexual Stimulation
# 200-1000 mcg before intercourse
PEPTIDES & SUPPLEMENTS YOU COULD STACK WITH
• Any GHRP (GHRP-2, GHRP-6, Ipamorelin, Hexarelin)
• Any GHRH (CJC-1295, MOD-GRF-1295, Tesamorelin)
• AOD-9604
• Semaglutide/Tirezepatice
• PT-141
• VIP
• Kisspeptin-10
• Masculine Medicine
PROS & CONS
PROS
• Melanotan I is FDA-approved
• Great peptides to increase skin tone
CONS
• Melanotan II can be beneficial for erectile dysfunction
• It takes more skill to use these peptides. Too much can lead to side
effects
• It has more side effects than most peptides
OVERALL OPINION
• Melanotan I and Melanotan II are powerful peptides that, use in the
right way, can be great
• I have personally used Melanotan II and like the tanning benefits, and
I am still exploring the sexual benefits
• If I were new to peptides and wanted to focus on the tanning benefits,
I would personally start with Melanotan I.
• Melanotan II can be harder to use since it is more intense with a
higher side-effect profile
